The folding interactome of GPCRs
نویسندگان
چکیده
Background The A2A adenosine receptor is a prototypical G proteincoupled receptor. It is expressed in a wide variety of cells including as different types as neurons, platelets, cells of the immune system and muscle. The A2A receptor has an unusually long C-terminus (of >120 residues), which for the most part is dispensable for coupling to Gs. This C-terminus turned out to be the docking site for other proteins. Using a yeast-2-hybrid screen we have previously identified proteins interacting with the C-terminus including ARNO/cytohesin2, SAP102 and USP4.
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2011